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Ligand design for G protein-coupled receptors / edited by Didier Rognan.

Contributor(s): Series: Methods and principles in medicinal chemistry ; vol. 30Publication details: Weinheim : Wiley-VCH, c2006.Description: xx, 264 p. : ill. (some col.) ; 25 cmISBN:
  • 3527312846 (hbk.)
  • 9783527312849 (hbk.)
Subject(s): DDC classification:
  • 541.2242 LIG
Contents:
Preface. - 1. G Protein-coupled receptors in the human genome. - 2. Why G Protein-coupled receptors databases are needed. - 3. A novel drug screening assay for G Protein-coupled receptors. - 4. Importance of GPCR dimerization for function: the case of the class C GPCRs. - 5. Molecular mechanism of GPCR activation. - 6. Allosteric properties and regulation of G Protein-coupled receptors. - 7. Chemogenomics approaches to Ligand design. - 8. Strategies for the design of pGPCR-targeted libraries. - 9. Ligand-based rational design: virtual screening. - 10. 3-D structure of G Protein-coupled receptors. - 11. 7TM models in structure-based drug design. - 12. Receptor-based rational design: virtual screening. - Subject index.
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Includes bibliographical references and index.

Preface. - 1. G Protein-coupled receptors in the human genome. - 2. Why G Protein-coupled receptors databases are needed. - 3. A novel drug screening assay for G Protein-coupled receptors. - 4. Importance of GPCR dimerization for function: the case of the class C GPCRs. - 5. Molecular mechanism of GPCR activation. - 6. Allosteric properties and regulation of G Protein-coupled receptors. - 7. Chemogenomics approaches to Ligand design. - 8. Strategies for the design of pGPCR-targeted libraries. - 9. Ligand-based rational design: virtual screening. - 10. 3-D structure of G Protein-coupled receptors. - 11. 7TM models in structure-based drug design. - 12. Receptor-based rational design: virtual screening. - Subject index.