Julious, Steven A.
An introduction to statistics in early phase trials / Steven A. Julious, Say Beng Tan, David Machin. - The Atrium, Southern Gate, Chichester, West Sussex, UK ; Hoboken, NJ : Wiley-Blackwell, 2010. - 263 p. : ill. ; 26 cm.
Includes bibliographical references and index.
Early phase trials -- Introduction to pharmacokinetics -- Sample size calculations for clinical trials -- Crossover trial basics -- Multi-period crossover trials -- First time into man -- Bayesian and frequentist methods -- First-time-into-new-population studies -- Bioequivalence studies -- Other phase I trials -- Phase II trials : general issues -- Dose-response studies -- Phase II trials with toxic therapies -- Interpreting and applying early phase trial results -- Go/no-go criteria.
9780470059852 (hbk.) 0470059850 (hbk.)
Drugs--Testing--Statistical methods.
Clinical trials--Statistical methods.
615.1901 / JUL 2010
An introduction to statistics in early phase trials / Steven A. Julious, Say Beng Tan, David Machin. - The Atrium, Southern Gate, Chichester, West Sussex, UK ; Hoboken, NJ : Wiley-Blackwell, 2010. - 263 p. : ill. ; 26 cm.
Includes bibliographical references and index.
Early phase trials -- Introduction to pharmacokinetics -- Sample size calculations for clinical trials -- Crossover trial basics -- Multi-period crossover trials -- First time into man -- Bayesian and frequentist methods -- First-time-into-new-population studies -- Bioequivalence studies -- Other phase I trials -- Phase II trials : general issues -- Dose-response studies -- Phase II trials with toxic therapies -- Interpreting and applying early phase trial results -- Go/no-go criteria.
9780470059852 (hbk.) 0470059850 (hbk.)
Drugs--Testing--Statistical methods.
Clinical trials--Statistical methods.
615.1901 / JUL 2010