Fragment-based approaches in drug discovery /
edited by Wolfgang Jahnke and Daniel A. Erlanson.
- Weinheim : Wiley-VCH, c2006
- xxii, 369 p. : ill. (some col.) ; 25 cm.
- Methods and principles in medicinal chemistry ; v. 34 .
Includes bibliographical references and index
1 The concept of fragment-based drug discovery / Daniel A. Erlanson, Wolfgang Jahnke. - 2. Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, George M. Whitesides. - 3. Entropic consequences of linking ligands / Christopher W. Murray, Marcel L. Verdonk. - 4. Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe, Carla Mattos. - 5. Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea, Jeffrey M. Blaney. - 6. Structural fragments in marketed oral drugs / Michal Vieth, Miles Siegel. - 7. Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz, Martin Karplus. - 8. NMR-guided fragment assembly / Daniel S. Sem. - 9. SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, Chaohong Sun. - 10. Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, Harren Jhoti. - 11. Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, Stephen K. Burley. - 12. Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, Vincent S. Stoll. - 13. Ligand SAR using electrospray ionization mass spectrometry / Richard H. Griffey, Eric E. Swayze. - 14. Tethering / Daniel A. Erlanson, Marcus D. Ballinger, James A. Wells. - 15. Click chemistry for drug discovery / Stefanie Roper, Hartmuth C. Kolb. - 16. Dynamic combinatorial diversity in drug discovery / Matthias Hochgurtel, Jean-Marie Lehn. - Index.
3527312919 (hbk.) 9783527312917 (hbk.)
Drug development
Ligands (Biochemistry)
615.1901 / FRA
Includes bibliographical references and index
1 The concept of fragment-based drug discovery / Daniel A. Erlanson, Wolfgang Jahnke. - 2. Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, George M. Whitesides. - 3. Entropic consequences of linking ligands / Christopher W. Murray, Marcel L. Verdonk. - 4. Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe, Carla Mattos. - 5. Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea, Jeffrey M. Blaney. - 6. Structural fragments in marketed oral drugs / Michal Vieth, Miles Siegel. - 7. Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz, Martin Karplus. - 8. NMR-guided fragment assembly / Daniel S. Sem. - 9. SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, Chaohong Sun. - 10. Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, Harren Jhoti. - 11. Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, Stephen K. Burley. - 12. Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, Vincent S. Stoll. - 13. Ligand SAR using electrospray ionization mass spectrometry / Richard H. Griffey, Eric E. Swayze. - 14. Tethering / Daniel A. Erlanson, Marcus D. Ballinger, James A. Wells. - 15. Click chemistry for drug discovery / Stefanie Roper, Hartmuth C. Kolb. - 16. Dynamic combinatorial diversity in drug discovery / Matthias Hochgurtel, Jean-Marie Lehn. - Index.
3527312919 (hbk.) 9783527312917 (hbk.)
Drug development
Ligands (Biochemistry)
615.1901 / FRA