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Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists / Robert A. Copeland.

By: Copeland, Robert Allen.
Series: Methods of biochemical analysis ; v. 46. Publisher: Hoboken, N.J. : Wiley-Interscience, 2005Description: xvii, 271 p. : ill. ; 25 cm.ISBN: 0471686964 (hbk.).Subject(s): Enzyme inhibitors -- Therapeutic use -- Testing | Drugs -- Design | Enzyme inhibitors -- Structure-activity relationshipsDDC classification: 615.19
Contents:
Foreword. - Preface. - Acknowledgments. - 1. Why enzymes as drug targets? - 2. Enzyme reaction mechanisms. - 3. Reversible modes of inhibitor interactions with enzymes. - 4. Assay considerations for compound library screening. - 5. Lead optimization and structrue-activity relationships for reversible inhibitors. - 6. Slow binding inhibitors. - 7. Tight binding inhibitors. - 8. Irreversible enzyme inactivators. - Appendix 1. Kinetics of biochemical reactions. - Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. - Appendix 3. Serial dilution schemes. - Index.
Item type Current location Call number Copy number Status Notes Date due Barcode Remark
Main Collection TU External Storage-LCS
615.19 COP (Browse shelf) 1 Available SBSxx,36100,03,GR 5000079837 Please fill up online form at https://taylorslibrary.taylors.edu.my/services/external_storage1

Includes bibliographical references and index.

Foreword. - Preface. - Acknowledgments. - 1. Why enzymes as drug targets? - 2. Enzyme reaction mechanisms. - 3. Reversible modes of inhibitor interactions with enzymes. - 4. Assay considerations for compound library screening. - 5. Lead optimization and structrue-activity relationships for reversible inhibitors. - 6. Slow binding inhibitors. - 7. Tight binding inhibitors. - 8. Irreversible enzyme inactivators. - Appendix 1. Kinetics of biochemical reactions. - Appendix 2. Derivation of the enzyme-ligand binding isotherm equation. - Appendix 3. Serial dilution schemes. - Index.