A pharmacology primer : theory, applications, and methods /
Terry P. Kenakin.
- 3rd ed.
- Burlington : Elsevier/Academic Press, c2009.
- xix, 389 p. : ill. (some col.) ; 29 cm.
Includes bibliographical references and index.
What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.