TY  - BOOK
AU  - Julious,Steven A.
AU  - Machin,David
AU  - Tan,Say Beng
TI  - An introduction to statistics in early phase trials
SN  - 9780470059852 (hbk.)
U1  - 615.1901 
PY  - 2010///
CY  - The Atrium, Southern Gate, Chichester, West Sussex, UK, Hoboken, NJ
PB  - Wiley-Blackwell
KW  - Drugs
KW  - Testing
KW  - Statistical methods
KW  - Clinical trials
N1  - Includes bibliographical references and index; Early phase trials -- Introduction to pharmacokinetics -- Sample size calculations for clinical trials -- Crossover trial basics -- Multi-period crossover trials -- First time into man -- Bayesian and frequentist methods -- First-time-into-new-population studies -- Bioequivalence studies -- Other phase I trials -- Phase II trials : general issues -- Dose-response studies -- Phase II trials with toxic therapies -- Interpreting and applying early phase trial results -- Go/no-go criteria
ER  -