Biotransformation and metabolite elucidation of xenobiotics /
edited by Ala F. Nassar.
- Hoboken, N.J. : John Wiley, c2010.
- xi, 328 p. : ill. ; 25 cm.
"Characterization and identification"--Cover.
Includes bibliographical references and index.
Human biotransformation / Andrew Parkinson -- Analytical tools and approaches for metabolite identification in drug metabolism / Yongmei Li -- Tools of choice for accelerating metabolite identification : mass spec technology drives metabolite identification studies forward / Ala Nassar -- Improving drug design : considerations for the structural modification process / Ala Nassar -- Case study : the unanticipated loss of N2 from novel dna alkylating agent laromustine by collision-induced dissociation : novel rearrangements / Ala Nassar, Tukiet T. Lam -- Case study : identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine / Ala Nassar, TuKiet T. Lam -- Strategies for the detection of reactive intermediates in drug discovery and development / Mark P. Grillo -- Safety testing of drug metabolites : MIST guidance impact on the practice of industrial drug metabolism / J. Greg Slatter.