Applied biopharmaceutics & pharmacokinetics /
Applied biopharmaceutics and pharmacokinetics
Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.
- 5th ed.
- New York : McGraw-Hill/Medical Pub. Division, c2005.
- xx, 892 p. : ill. ; 24 cm.
Preface. - Glossary. - Ch. 1. Introduction to Biopharmaceutics and Pharmacokinetics. - Ch. 2. Mathematic Fundamentals in Pharmacokinetics. - Ch. 3. One Compartment Open Model - Intravenous Bolus Administration. Ch. 4. Multicompartmental Models - Intravenous Bolus Administration. - Ch. 5. Intravenous Infusion. - Ch. 6. Drug Elimination and Clearance. - Ch. 7. Pharmacokinetics of Oral Absorption. - Ch. 8. Multiple Dosage Regimens. - Ch. 9. Nonlinear Pharmacokinetics. - Ch. 10. Physiologic Drug Distribution and Protein Binding. - Ch. 11. Renal and Hepatic Elimination of Drugs. - Ch. 12. Pharmacogenetics. - Ch. 13. Physiologic Factors Related to Drug Absorption. - Ch. 14. Biopharmaceutic Considerations in Drug Product Design. - Ch. 15. Bioavailability and Bioequivalence. - Ch. 16. Impact of Drug Product Quality and Biopharmaceutics on Clinical Efficacy. - Ch. 17. Modified Release Drug Products. - Ch. 18. Targeted Drug Delivery Systems and Biotechnology Products. - Ch. 19. Relationship between Pharmacokinetic and Pharmacodynamics. - Ch. 20. Application of Pharmacokinetics in Clinical Situations. - Ch. 21. Dosage Adjustment in Renal and Hepatic Disease. - Ch. 22. Physiological Pharmacokinetic Models, Mean Resident Time and Statistical Moment Theory. - Appendix A. Statistics. - Appendix B. Applications of Computers in Pharmacokinetics. - Appendix C. Ethical Considerations. - Appendix D. Solutions to Frequently Asked Questions (FAQ) and Learning Questions. - Appendix E. Popular Drugs and Pharmacokinetic Parameters. - Index.