TY  - BOOK
AU  - Rognan,Didier
TI  - Ligand design for G protein-coupled receptors
SN  - 3527312846 (hbk.)
U1  - 541.2242 
PY  - 2006///
CY  - Weinheim
PB  - Wiley-VCH
KW  - Ligands (Biochemistry)
KW  - G proteins
KW  - Drugs
KW  - Design
N1  - Includes bibliographical references and index; Preface. - 1. G Protein-coupled receptors in the human genome. - 2. Why G Protein-coupled receptors databases are needed. - 3. A novel drug screening assay for G Protein-coupled receptors. - 4. Importance of GPCR dimerization for function: the case of the class C GPCRs. - 5. Molecular mechanism of GPCR activation. - 6. Allosteric properties and regulation of G Protein-coupled receptors. - 7. Chemogenomics approaches to Ligand design. - 8. Strategies for the design of pGPCR-targeted libraries. - 9. Ligand-based rational design: virtual screening. - 10. 3-D structure of G Protein-coupled receptors. - 11. 7TM models in structure-based drug design. - 12. Receptor-based rational design: virtual screening. - Subject index
ER  -