Senn, Stephen. <br/><br/>
Statistical issues in drug development  [electronic resource] / 
Stephen Senn. 
 - 2nd ed. 
 - Chichester, England ;  Hoboken, NJ :  John Wiley,  c2007. 
 - xix, 498 p. :  ill. ;  25 cm. 
 - Statistics in practice .
<br/><br/>Includes bibliographical references and index. 
<br/><br/>A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmaceutical statistician -- Allocating treatments to patients in clinical trials -- Baselines and covariate information -- The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-values -- Determining the sample size -- Multicentre trials -- Active control equivalence studies -- Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco-economics and portfolio management -- Concerning pharmacogenetics, pharmacogenomics, and related matters. 
<br/><br/><br/>Electronic reproduction. <br/>Palo Alto, Calif. : <br/>ebrary, <br/>2009. <br/>Available via World Wide Web. <br/>Access may be limited to ebrary affiliated libraries. 
<br/><br/><label>ISBN: </label>
<br/><br/><label>LCCN: </label>
<br/><br/><label>Nat. Bib. Agency Control No.: </label> DNLM 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Drug development--Statistical methods.
<br/><br/><label>Index Terms--Genre/Form: </label><br/>Electronic books.
<br/><br/><label>LC Class. No.: </label>RM301.25  / .S46 2007eb 
<br/><br/><label>Dewey Class. No.: </label>615/.190727