Proteomics in drug research / edited by Michael Hamacher ... [et al.]. - Weinheim : Wiley-VCH, c2006. - xxi, 362 p. : ill. ; 25 cm. - Methods and principles in medicinal chemistry ; v. 28 .

Includes bibliographical references and index.

A personal foreword. - Preface. - List of contributors. - I. Introduction. 1. Administrative optimization of proteomics networks for drug development / Andre van Hall, Michael Hamacher. 2. Proteomic data standardization, deposition and exchange / Sandra Orchard, Henning Hermjakob, Manuela Pruess, Rolf Apweiler. - II. Proteomic technologies. 3. Difference gel electrophoresis (DIGE) : the next generation of two-dimensional gel electrophoresis for clinical research / Barbara Sitek, Burghardt Scheibe, Klaus Jung, Alexander Schramm, Kai Stuhler. 4. Biological mass spectrometry : basics and drug discovery related approaches / Bettina Warscheid. 5. Multidimensional column liquid chromatography (LC) in proteomics - where are we now? / Egidijus Machtejevas, Klaus K. Unger, Reinhard Ditz. 6. Peptidomics technologies and applications in drug research / Michael Schrader, Petra Budde, Horst Rose, Norbert Lamping, Peter Schulz-Knappe, Hans-Dieter Zucht. 7. Protein biochips in the proteomic field / Angelika Lucking, Dolores J. Cahill. 8. Current developments for the in vitro characterization of protein interactions / Daniela Moll, Bastian Zimmermann, Frank Gesellchen, Friedrich W. Herberg. 9. Molecular networks in morphologically intact cells and tissue-challenge for biology and drug development / Walter Schubert, Manuela Friedenberger, Marcus Bode. - III. Application. 10. From target to lead synthesis / Stefan Mullner, Holger Stark, Paivi Niskanen, Erich Eigenbrodt, Sybille Mazurek, Hugo Fasold. 11. Differential phosphoproteome analysis in medical research / Elke Butt, Katrin Marcus. 12. Biomarker discovery in renal cell carcinoma applying proteome-based studies in combination with serology / Barbara Seliger, Roland Kellner. 13. Studies of drug resistance using organelle proteomics / Catherine Fenselau, Zongming Fu. 14. Clinical neuroproteomics of human body fluids : CSF and blood assays for early and differential diagnosis of dementia / Jens Wiltfang, Piotr Lewczuk. 15 Proteomics in Alzheimer's disease / Michael Fountoulakis, Sophia Kossida, Gert Lubec. 16. Cardiac proteomics / Emma McGregor, Michael J. Dunn. - IV. To the market. 17. Innovation processes / Sven Ruger. - Subject index.

3527312269 (hbk.) 9783527312269 (hbk.)

2006-296549


Proteomics.
Drugs--Research.

572.6 / PRO