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Computer applications in pharmaceutical research and development / [edited by] Sean Ekins.

Contributor(s): Series: Wiley series in drug discovery and developmentPublication details: Hoboken, N.J. : Wiley-Interscience, c2006.Description: xix, 805 p., [12] p. of plates : ill. (some col.) ; 25 cmISBN:
  • 0471737798 (hbk.)
  • 9780471737797 (hbk.)
Subject(s): DDC classification:
  • 615.10285 COM
Contents:
Preface. -Acknowledgments. - Contributors. - Pt. 1: Computers in pharmaceutical research and development: a general overview. - 1. History of computers in pharmaceutical research and development: a narrative / Donald B. Boyd and Max M. Marsh. - 2. Computers as data analysis and data management tools in preclinical development / Weiyong Li and Kenneth Banks. - 3. Statistical modeling in pharmaceutical research and development / Andrea de Gaetano ... [et al.]. - Pt. II: Understanding diseases: mining complex systems for knowledge. - 4. Drug discovery from historic herbal texts / Eric J. Buenz. -5. Contextualizing the impact of bioinformatics on preclinical drug and vaccine discovery / Darren R. Flower. - 6. Systems approaches for pharmaceutical research and development / Sean Ekins and Craig Giroux. - Pt. III: Scientific information handling and enhancing productivity. - 7. Information management-biodata in life sciences / Richard K. Scott and Anthony Parsons. - 8. Chemoinformatics techniques for processing chemical structure databases / Valerie J. Gillet and Peter Willett. - 9. Electronic laboratory notebooks / Alfred Nehme and Robert A. Scoffin. - 10. Strategies for using information effectively in early-stage drug discovery / David J. Wild. - 11. Improving the pharmaceutical R&D process: how simulation can support management decision making / Andrew Chadwick ... [et al.]. - Pt. IV: Computers in drug discovery. - 12.
Computers and protein crystallography / David J. Edwards and Roderick E. Hubbard. - 13. Computers, cheminformatics, and the medicinal chemist / Weifan Zheng and Michael Jones. - 14. The challenges of making useful protein-ligand free energy predictions for drug discovery / Jun Shimada. - 15. Computer algorithms for selecting molecule libraries for synthesis / Konstantin V. Balakin, Nikolay P. Savchuk, and Alex Kiselyov. - 16. Success stories of computer-aided design / Hugo Kubinyi. - 17. Pharmaceutical research and development productivity: can software help? / Christophe Lambert and S. Stanley Young. - Pt. V: Computers in preclinical development. - 18. Computer methods for predicting drug metabolism / Sean Ekins. - 19. Computers in toxicology and risk assessment / John C. Dearden. - 20. Computational modeling of drug disposition / Cheng Chang and Peter W. Swaan. - 21. Computer simulations in pharmacokinetics and pharmacodynamics: rediscovering systems physiology in the 21st century / Paolo Vicin. - 22. Predictive models for better decisions from understanding physiology to optimizing trial design / James R. Bosley, Jr. - Pt. VI: Computers in development decision making, economics, and market analysis. - 23.
Making pharmaceutical development more efficient / Michael Rosenberg and Richard Farris. - 24. Use of interactive software in m. - Pt. VII: Computers in clinical development. - 25. Clinical data . - 26. - Regulation of computer systems / Sandy Weinberg. - 27. A new paradigm for analyzing adverse drug events / Ana Szarfman, Jonathan G. Levine and Joseph M. Tonning. - Pt. VIII: Further applications and future development.28. Computers in pharmaceutical formulation / Raymond C. Rowe and Elizabeth A. Colbourn. - 29. Legal protection of innovative uses of computers in R&D / Robert Harrison. - 30. The ethics of computing in pharmaceutical research / Matthew K. McGowan and Richard J. McGowan. - 31. The UltraLink: an expert system for contextual hyperlinking in knowledge management / Martin Romacker ... [et al.]. - 32. Powerful, predictive and pervasive: the future of computers in the pharmaceutical industry / Nick Davies, Heather Ahlborn, Stuart Henderson. - Index.
Holdings
Cover image Item type Current library Home library Collection Shelving location Shelf location Call number Materials specified Vol info Copy number Status Notes Date due Barcode Item holds Item hold queue priority Course reserves
Main Collection Taylor's Library-TU

Floor 4, Shelf 17 , Side 2, TierNo 3, BayNo 5

 615.10285 COM (Browse shelf(Opens below)) 1 Available SBSxx,36100,03,GR 5000084655

Includes bibliographical references and index.

Preface. -Acknowledgments. - Contributors. - Pt. 1: Computers in pharmaceutical research and development: a general overview. - 1. History of computers in pharmaceutical research and development: a narrative / Donald B. Boyd and Max M. Marsh. - 2. Computers as data analysis and data management tools in preclinical development / Weiyong Li and Kenneth Banks. - 3. Statistical modeling in pharmaceutical research and development / Andrea de Gaetano ... [et al.]. - Pt. II: Understanding diseases: mining complex systems for knowledge. - 4. Drug discovery from historic herbal texts / Eric J. Buenz. -5. Contextualizing the impact of bioinformatics on preclinical drug and vaccine discovery / Darren R. Flower. - 6. Systems approaches for pharmaceutical research and development / Sean Ekins and Craig Giroux. - Pt. III: Scientific information handling and enhancing productivity. - 7. Information management-biodata in life sciences / Richard K. Scott and Anthony Parsons. - 8. Chemoinformatics techniques for processing chemical structure databases / Valerie J. Gillet and Peter Willett. - 9. Electronic laboratory notebooks / Alfred Nehme and Robert A. Scoffin. - 10. Strategies for using information effectively in early-stage drug discovery / David J. Wild. - 11. Improving the pharmaceutical R&D process: how simulation can support management decision making / Andrew Chadwick ... [et al.]. - Pt. IV: Computers in drug discovery. - 12.

Computers and protein crystallography / David J. Edwards and Roderick E. Hubbard. - 13. Computers, cheminformatics, and the medicinal chemist / Weifan Zheng and Michael Jones. - 14. The challenges of making useful protein-ligand free energy predictions for drug discovery / Jun Shimada. - 15. Computer algorithms for selecting molecule libraries for synthesis / Konstantin V. Balakin, Nikolay P. Savchuk, and Alex Kiselyov. - 16. Success stories of computer-aided design / Hugo Kubinyi. - 17. Pharmaceutical research and development productivity: can software help? / Christophe Lambert and S. Stanley Young. - Pt. V: Computers in preclinical development. - 18. Computer methods for predicting drug metabolism / Sean Ekins. - 19. Computers in toxicology and risk assessment / John C. Dearden. - 20. Computational modeling of drug disposition / Cheng Chang and Peter W. Swaan. - 21. Computer simulations in pharmacokinetics and pharmacodynamics: rediscovering systems physiology in the 21st century / Paolo Vicin. - 22. Predictive models for better decisions from understanding physiology to optimizing trial design / James R. Bosley, Jr. - Pt. VI: Computers in development decision making, economics, and market analysis. - 23.

Making pharmaceutical development more efficient / Michael Rosenberg and Richard Farris. - 24. Use of interactive software in m. - Pt. VII: Computers in clinical development. - 25. Clinical data . - 26. - Regulation of computer systems / Sandy Weinberg. - 27. A new paradigm for analyzing adverse drug events / Ana Szarfman, Jonathan G. Levine and Joseph M. Tonning. - Pt. VIII: Further applications and future development.28. Computers in pharmaceutical formulation / Raymond C. Rowe and Elizabeth A. Colbourn. - 29. Legal protection of innovative uses of computers in R&D / Robert Harrison. - 30. The ethics of computing in pharmaceutical research / Matthew K. McGowan and Richard J. McGowan. - 31. The UltraLink: an expert system for contextual hyperlinking in knowledge management / Martin Romacker ... [et al.]. - 32. Powerful, predictive and pervasive: the future of computers in the pharmaceutical industry / Nick Davies, Heather Ahlborn, Stuart Henderson. - Index.