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Evaluation of drug candidates for preclinical development : pharmacokinetics, metabolism, pharmaceutics, and toxicology / edited by Chao Han, Charles B. Davis, Binghe Wang.

Contributor(s): Series: Wiley series in drug discovery and developmentPublication details: Hoboken, N.J. : John Wiley, c2010.Description: x, 289 p., [2] p. of plates : ill. (some col.) ; 25 cmISBN:
  • 9780470044919 (hbk.)
Subject(s): DDC classification:
  • 615.19 EVA 2010
Contents:
Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Ramesh Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, and Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.
Holdings
Cover image Item type Current library Home library Collection Shelving location Shelf location Call number Materials specified Vol info Copy number Status Notes Date due Barcode Item holds Item hold queue priority Course reserves
Main Collection Taylor's Library-TU 615.19 EVA 2010 (Browse shelf(Opens below)) 1 Available SOPxx,31001,03,CL 5000103389

Includes bibliographical references and index.

Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Ramesh Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, and Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.