Ligand design for G protein-coupled receptors / edited by Didier Rognan.
Contributor(s): Rognan, Didier [(ed.)].
Series: Methods and principles in medicinal chemistry ; vol. 30. Publisher: Weinheim : Wiley-VCH, c2006Description: xx, 264 p. : ill. (some col.) ; 25 cm.ISBN: 3527312846 (hbk.); 9783527312849 (hbk.).Subject(s): Ligands (Biochemistry) | G proteins | Drugs -- DesignDDC classification: 541.2242Item type | Current location | Call number | Copy number | Status | Notes | Date due | Barcode | Remark |
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Main Collection | TU External Storage-LCS | 541.2242 LIG (Browse shelf) | 1 | Available | SBSxx,36200,03,GR | 5000070654 | Please fill up online form at https://taylorslibrary.taylors.edu.my/services/external_storage1 |
Includes bibliographical references and index.
Preface. - 1. G Protein-coupled receptors in the human genome. - 2. Why G Protein-coupled receptors databases are needed. - 3. A novel drug screening assay for G Protein-coupled receptors. - 4. Importance of GPCR dimerization for function: the case of the class C GPCRs. - 5. Molecular mechanism of GPCR activation. - 6. Allosteric properties and regulation of G Protein-coupled receptors. - 7. Chemogenomics approaches to Ligand design. - 8. Strategies for the design of pGPCR-targeted libraries. - 9. Ligand-based rational design: virtual screening. - 10. 3-D structure of G Protein-coupled receptors. - 11. 7TM models in structure-based drug design. - 12. Receptor-based rational design: virtual screening. - Subject index.