000			01326cam a2200265 a 4500
001			vtls003227445
003			MY-SjTCS
005			20200226121451.0
008			111206s2011 flua b 001 0 eng
020			_a9781420091519 (hbk.)
020			_a1420091514 (hbk.)
039		9	_a201203131519 _bwilmina _c201202281651 _dmalathy _y201112061127 _zmalathy
082	0	4	_a615.1 _bCHE 2011
100	1		_aCheung, Ying Kuen. _958234
245	1	0	_aDose finding by the continual reassessment method / _cYing Kuen Cheung.
260			_aBoca Raton : _bCRC Press, _cc2011.
300			_axv, 189 p. : _bill. ; _c25 cm.
490	1		_aChapman & Hall/CRC biostatistics series
504			_aIncludes bibliographical references and index.
505	0		_aDose finding in clinical trials -- The continual reassessment method -- One-parameter dose toxicity models -- Theoretical properties -- Empirical properties -- Specifications of a CRM design -- Initial guesses of toxicity probabilities -- Least informative normal prior -- Initial design -- The time-to-event CRM -- CRM with multiparameter models -- When the CRM fails -- Stochastic approximation.
650		0	_aDrugs _xDose-response relationship. _947478
650		0	_aClinical trials. _924193
830		0	_aChapman & Hall/CRC biostatistics series ; _v41. _956200
920			_aPHA : 177459
999			_c183473