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005			20200306170310.0
008			110218s2005 enkda b 001 0 eng
020			_a0470857560 (hbk.)
039		9	_a201102181353 _bVLOAD _c200705071217 _dIrma _c200704130927 _dradtha _c200704111004 _dradtha _y200704110805 _zradtha
082	0	4	_a616.994071 _bREC
245	0	0	_aRecent advances in quantitative methods in cancer and human health risk assessment / _cedited by Lutz Edler, Christos P. Kitsos.
260			_aChichester, England : _bJ. Wiley, _cc2005.
300			_axxviii, 463 p. : _bill. ; _c24 cm.
440		0	_aWiley series in probability and statistics _99765
505	0		_aContributors. - Preface. - Introduction. - I: Cancer and human health risk assessment. - 1. Principles of cancer risk assessment: The risk assessment paradigm. - II: Biological aspects of Carcinogenesis. - 2. Molecular epidemiology in cancer research. - 3. Genetic polymorphisms in metabolising enzymes as lung cancer risk factors. - 4. Biological and mathematical aspects of multistage carcinogenesis . - 6. Risk assessment and chemical and radiation hormesis: A short commentary and bibliographic review. - III: Modeling for cancer risk assessment. - 7. Modeling exposure and target organ concentrations. - 8. Stochastic carcinogenesis models. - 9. A unified modeling approach: From exposure to disease endpoints. - 10. Modeling lung cancer screening. - 11. Optimal regimens of cancer screening. - IV: Statistical approaches for carcinogenesis studies. - 12. Analysis of survival data with non-proportional hazards and crossings of survival functions. - 13. Dose response modeling. - 14. Benchmark dose approach. - 15. Uncertainty analysis: the Bayesian approach. - 16. Optimal designs for bioassays in carcinogenesis. - V: Specific modeling approaches for health risk assessment. - 17. Cancer risk assessment for mixtures. - 18. Designs and models for mixtures: Assessing cumulative risk. - 19. Estimating the natural history of breast cancer from bivariate data on age and tumor size at diagnosis. - VI: Case studies. - 20. Statistical issues in search for biomarkers of colorectal cancer using microarray experiments. - 21. Optimal experimental designs for prediction of morbidity after lung resection. - 22. Logistic regression methods and their implementation. - 23. The use of logistic regression, discriminant analysis and classification trees to predict holding on remission in childhood leukemia. - 24. Non-melanoma skin and lung cancer incidence in relation to arsenic exposure: 20 years of observation. - 25. Thyroid cancer incidence rates in Zaragoza. - References. - Index.
650		0	_aCancer _xRisk factors _xMathematical models. _9282924
700	1		_aEdler, Lutz, _d1945- _e(ed.) _9282925
700	1		_aKitsos, Christos Par., _d1951- _e(j.ed.) _9282926
920			_aBMS : 261056
999			_c61373 _d61373