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Fragment-based approaches in drug discovery / edited by Wolfgang Jahnke and Daniel A. Erlanson.

Contributor(s): Series: Methods and principles in medicinal chemistry ; v. 34Publication details: Weinheim : Wiley-VCH, c2006Description: xxii, 369 p. : ill. (some col.) ; 25 cmISBN:
  • 3527312919 (hbk.)
  • 9783527312917 (hbk.)
Subject(s): DDC classification:
  • 615.1901 FRA
Contents:
1 The concept of fragment-based drug discovery / Daniel A. Erlanson, Wolfgang Jahnke. - 2. Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, George M. Whitesides. - 3. Entropic consequences of linking ligands / Christopher W. Murray, Marcel L. Verdonk. - 4. Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe, Carla Mattos. - 5. Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea, Jeffrey M. Blaney. - 6. Structural fragments in marketed oral drugs / Michal Vieth, Miles Siegel. - 7. Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz, Martin Karplus. - 8. NMR-guided fragment assembly / Daniel S. Sem. - 9. SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, Chaohong Sun. - 10. Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, Harren Jhoti. - 11. Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, Stephen K. Burley. - 12. Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, Vincent S. Stoll. - 13. Ligand SAR using electrospray ionization mass spectrometry / Richard H. Griffey, Eric E. Swayze. - 14. Tethering / Daniel A. Erlanson, Marcus D. Ballinger, James A. Wells. - 15. Click chemistry for drug discovery / Stefanie Roper, Hartmuth C. Kolb. - 16. Dynamic combinatorial diversity in drug discovery / Matthias Hochgurtel, Jean-Marie Lehn. - Index.
Holdings
Cover image Item type Current library Home library Collection Shelving location Shelf location Call number Materials specified Vol info Copy number Status Notes Date due Barcode Item holds Item hold queue priority Course reserves
Main Collection Taylor's Library-TU

Floor 4, Shelf 17 , Side 2, TierNo 3, BayNo 8

 615.1901 FRA (Browse shelf(Opens below)) 1 Available SBSxx,36100,03,GR 5000079160

Includes bibliographical references and index

1 The concept of fragment-based drug discovery / Daniel A. Erlanson, Wolfgang Jahnke. - 2. Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, George M. Whitesides. - 3. Entropic consequences of linking ligands / Christopher W. Murray, Marcel L. Verdonk. - 4. Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe, Carla Mattos. - 5. Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea, Jeffrey M. Blaney. - 6. Structural fragments in marketed oral drugs / Michal Vieth, Miles Siegel. - 7. Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz, Martin Karplus. - 8. NMR-guided fragment assembly / Daniel S. Sem. - 9. SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, Chaohong Sun. - 10. Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, Harren Jhoti. - 11. Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, Stephen K. Burley. - 12. Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, Vincent S. Stoll. - 13. Ligand SAR using electrospray ionization mass spectrometry / Richard H. Griffey, Eric E. Swayze. - 14. Tethering / Daniel A. Erlanson, Marcus D. Ballinger, James A. Wells. - 15. Click chemistry for drug discovery / Stefanie Roper, Hartmuth C. Kolb. - 16. Dynamic combinatorial diversity in drug discovery / Matthias Hochgurtel, Jean-Marie Lehn. - Index.